Mode of Action

Hydrogen peroxide (H2O2)-mediated receptor signaling (Redox Signaling)

  • In the normal physiology, various receptor activations trigger production of intracellular hydrogen peroxide H2O2, which acts as a second messenger like calcium or cAMP. H2O2 induces oxidation of cysteine thiol on target proteins. Such oxidation causes conformation change and affect protein-protein interaction as well as activity. After the signal, it is eliminated by peroxiredoxin (Prx) enzyme through this coupling reaction.

    However, in the diseased state like inflammation or stress condition, high H2O2 level causes Prx enzyme inactivation and also overoxidation of target proteins as well as macromolecues. Consequently, the abnormal overoxidation causes the hyperplasia, damage, and dysfuction in the tissues. If we could replace the inactive Prx enzymes with stable chemical agents, we may control abnormal H2O2 level and hence normalize the cellular function. Our drug development starts from this new redox signaling.

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