Vasthera is developing global
first-in-class Vascular Therapeutics that reverse diseased blood arterial vessels.

Human blood vessels are the highways transporting ‘life’ throughout the body and it is known the total length is 120,000km. Our mission is to cure severe vascular diseases by restoring the damage occurred within 120,000km.

Vasthera is developing global
first-in-class Vascular Therapeutics that reverse diseased blood arterial vessels.

Human blood vessels are the highways transporting ‘life’ throughout the body and it is known the total length is 120,000km. Our mission is to cure severe vascular diseases by restoring the damage occurred within 120,000km.

SCIENCE

We have been studying the role of intracellular hydrogen peroxide (H2O2) in the redox signaling pathway. Since H2O2 acts as a second messenger, its uncontrolled level causes abnormal signal transduction and damage to the tissue. In normal physiology, Peroxiredoxin (Prx) and Glutathione peroxidase (Gpx) control intracellular level of H2O2. However, Prx and Gpx are inactivated or silenced in diseased state which increases the level of H2O2 leading to hyperplasia and dysfunction of tissues.

Mode of Action
Publications

Technology

With our innovative drug discovery platform, ENTER, VasThera is developing new small molecules that mimic Peroxiredoxin (Prx) and Glutathione peroxidase (Gpx) activities. Abnormal redox signaling driven by the inactivation of Prx or Gpx can lead to cardiovascular disease, cancer and neurodegenerative disease. If inactive Prx and Gpx enzymes are replaced with stable chemical compounds, abnormal redox signaling is controlled and hence normalize the cellular function. Therefore, we are currently advancing pipelines to indications with high unmet medical needs, such as pulmonary arterial hypertension (PAH) and triple negative breast cancer (TNBC).

Platform
Pipeline
Our company

Our company

Human blood vessels are the highways transporting ‘life’ throughout the body and it is known that the total length is 12,000 km. Our main focus is to cure severe and chronic vascular diseases by restoring damage occurred within 120,000 km.

Members

Members

  • SAB
  • Leadership
Vision & Value

Vision & Value

VasThera is an innovative pharmaceutical company
that develops the first-in-class synthetic therapeutics
targeting various diseases caused by vascular
lesions.

  • CONTACTS

    Headquarter: Room #504, Science Building C, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Republic of Korea
    Research institute: Room #251, University-Industry Cooperation Building, 150, Bugahyeon-ro, Seodaemun-gu, Seoul 03759, Republic of Korea

TOPTOP
검색 닫기